Androgen deprivation causes selective deficits in the biomechanical leg muscle function of men during walking: a prospective case–control study

AS Cheung; H Gray; AG Schache; R Hoermann; D Lim Joon; JD Zajac; MG Pandy; M Grossmann

Journal article

Androgen deprivation causes selective deficits in the biomechanical leg muscle function of men during walking: a prospective case–control study

AS Cheung, H Gray, AG Schache, R Hoermann, D Lim Joon, JD Zajac, MG Pandy, M Grossmann

Journal of Cachexia Sarcopenia and Muscle | WILEY | Published : 2017

DOI: 10.1002/jcsm.12133

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Abstract

Background: Although muscle mass declines with testosterone deficiency in men, previous studies of muscle function have not demonstrated consistent deficits, likely due to relatively insensitive methodology. Our objective was to determine the effects of testosterone deprivation on the biomechanical function of individual lower-limb muscles. Methods: We conducted a 12-month prospective, observational case–control study of 34 men newly commencing androgen deprivation treatment (ADT) for prostate cancer and 29 age-matched prostate cancer controls. Participants were assessed at 0, 6, and 12 months while walking in a biomechanics laboratory. We combined video-based motion capture and ground react..

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University of Melbourne Researchers

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Grants

Awarded by National Science Foundation

Funding Acknowledgements

This study was supported by a National Health and Medical Research Council of Australia (NHMRC) project grant (1006407). A. S. C. is supported by a NHMRC postgraduate scholarship (1017233) to undertake this project as part of a PhD. M. G. is supported by a NHMRC Career Development Fellowship (1024139). Support provided by an Australian Research Council Discovery Projects grant (DP1095366) and an Innovation Fellowship provided by the Victorian Endowment for Science, Knowledge, and Innovation to M. G. P. are also gratefully acknowledged.